Journal
EXPERIMENTAL DERMATOLOGY
Volume 12, Issue 4, Pages 412-417Publisher
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1600-0625.2003.00062.x
Keywords
neurofibroma; angiogenic factors; vascular endothelial growth factor; basic fibroblast growth factor
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We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis-1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT-PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.
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