Journal
DISEASES OF AQUATIC ORGANISMS
Volume 55, Issue 3, Pages 261-264Publisher
INTER-RESEARCH
DOI: 10.3354/dao055261
Keywords
oral vaccine; immunization; ayu; Flavobacterium psychrophilum; bacterial coldwater disease; BCWD
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The development of a practical vaccination method against bacterial coldwater disease (BCWD) in ayu Plecoglossus altivelis and the efficacy of oral administration of formalin-killed cells (FKCs) of Flavobacterium psychrophilum was investigated. The FKC was administrated at a dose of 0.1-0.2 g kg(-1) body weight to juvenile ayu (0.5 g body weight) every day for 2 wk or on 5 days over 2 wk. Experimental immersion challenge at 3 and 7 wk after vaccination showed significantly higher survival rates than the controls. The results show the effectiveness of oral vaccination against BCWD in ayu.
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