Journal
CURRENT OPINION IN LIPIDOLOGY
Volume 14, Issue 4, Pages 341-345Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00041433-200308000-00001
Keywords
sitosterol; plant sterols; ABCG5; ABCG8; intestine
Funding
- NHLBI NIH HHS [R01 HL068660] Funding Source: Medline
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Despite improvements in treatments for hypercholesterolemia with cholesterol lowering agents, cardiovascular disease still remains highly prevalent. This has prompted many to consider that molecules other than cholesterol may be better biomarkers for this disease and targeting these more directly may allow us to develop more effective therapies. Ideally, if such a biomarker were also the bioactive molecule that is key to initiating/ propagating the atherosclerosis pathogenic pathway, this would allow us to develop an optimal predictor and monitor of the disease process. One source of such molecules could come from our diet, with potential candidates such as noncholesterol sterols, oxysterols, oxidized sterols or some as yet unidentified dietary bioactive molecule. Nature has evolved a protective mechanism by which such molecules are kept out of the body, thereby reducing the negative effects of these compounds. The newly identified sterolin proteins involved in the absorption and excretion of dietary sterols may fit this bill. If so, we would speculate that a better biomarker may be lurking within their substrate specificities.
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