Journal
BRAIN RESEARCH
Volume 980, Issue 1, Pages 117-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)02946-9
Keywords
venlafaxine; neuropathic pain; antineoplasic drug; antidepressants; paw pressure; C reflex; rat
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Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms. (C) 2003 Elsevier B.V. All rights reserved.
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