Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 69, Issue 2-3, Pages 169-177Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/S0952-3278(03)00078-4
Keywords
prostaglandin D-2; G protein-coupled receptor; allergy
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Prostaglandin (PG) D-2 plays a broad range of physiological and pathophysiological functions. Until just a few years ago, it was thought that most of the biological actions of PGD(2) are mediated via the classical PGD(2) receptor DP. Recently, we identified a second PGD(2) receptor, chemoattractant receptor-homologous molecule expressed on T helper (Th)2 cells (CRTH2), with different functions relative to DP. Here, we review the recent findings on the structure, tissue distribution, ligand selectivity, signalling pathways, and functions in leukocytes of this receptor. The data suggest that the PGD(2)/CRTH2 system play important roles in allergic inflammation through its stimulatory effects on Th2 cells, cosinophils, and basophils. (C) 2003 Elsevier Science Ltd. All rights reserved.
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