Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 8, Pages 1136-1139Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030092g
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Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1 cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The structure of 1 including the absolute stereochemistry was determined by spectroscopic and chemical methods.
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