The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp No. 19353 II.: Biological profiles

The novel gluconeogenesis inhibitor FR225659 and four related compounds were isolated from the cultured broth of a fungal strain No. 19353. These compounds inhibited the glucagon-stimulated gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in two different in vivo models.