Journal
JOURNAL OF ANTIBIOTICS
Volume 56, Issue 8, Pages 689-693Publisher
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.56.689
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The novel gluconeogenesis inhibitor FR225659 and four related compounds were isolated from the cultured broth of a fungal strain No. 19353. These compounds inhibited the glucagon-stimulated gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in two different in vivo models.
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