Journal
DEVELOPMENT
Volume 130, Issue 16, Pages 3747-3755Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.00576
Keywords
Delta; Notch; oligodendrocytes; motoneurons; neural precursors; CNS; spinal cord; zebrafish
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Funding
- NCI NIH HHS [CA 68485] Funding Source: Medline
- NCRR NIH HHS [1S10 RR 15682-01] Funding Source: Medline
- NICHD NIH HHS [HD 38118] Funding Source: Medline
- NIDDK NIH HHS [DK 20593] Funding Source: Medline
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Oligodendrocytes, the myelinating cell type of the central nervous system, arise from a ventral population of precursors that also produces motoneurons. Although the mechanisms that specify motoneuron development are well described, the mechanisms that generate oligodendrocytes from the same precursor population are largely unknown. By analysing mutant zebrafish embryos, we found that Delta-Notch signaling is required for spinal cord oligodendrocyte specification. Using a transgenic, conditional expression system, we also learned that constitutive Notch activity could promote formation of excess oligodendrocyte progenitor cells (OPCs). However, excess OPCs are induced only in ventral spinal cord at the time that OPCs normally develop. Our data provide evidence that Notch signaling maintains subsets of ventral spinal cord precursors during neuronal birth and, acting with other temporally and spatially restricted factors, specifies them for oligodendrocyte fate.
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