Journal
NEUROCHEMICAL RESEARCH
Volume 28, Issue 8, Pages 1163-1173Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1024268126310
Keywords
hyperthermia; Hsp27; Hsp32; heat shock protein; vimentin; astrocytes; microglia
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In response to stressful stimuli, cells respond by inducing a set of heat shock ( stress) proteins ( hsps) that play important roles in repair and protective mechanisms. The present study investigates the expression patterns of Hsp27 and Hsp32 in the adult rat hippocampus following whole body hyperthermia. A pronounced induction of these low-molecular-weight stress proteins was apparent in populations of glial cells such as astrocytes and microglia that were identified using cell-specific markers (GFAP for astrocytes and the lectin GSA I-B4 for microglia). Hyperthermia also resulted in a robust induction of the intermediate filament protein, vimentin, in glial cells in the adult rat hippocampus. Interestingly, a rapid induction of both Hsp27 and vimentin was observed in the microvasculature, suggesting that hyperthermic stress may compromise the blood-brain barrier.
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