Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 69, Issue 2-3, Pages 99-109Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/S0952-3278(03)00070-X
Keywords
leukotrienes; compartmentalization; nucleus; catalysis; metabolon; calcium; kinases; inhibitors; expression
Funding
- NHLBI NIH HHS [R01-HL58897] Funding Source: Medline
- NIAID NIH HHS [R01-AI43574] Funding Source: Medline
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The initial steps in the biosynthesis of leukotrienes from arachidonic acid are carried out by the enzyme 5-lipoxygenase (5-LO). In intact cells, the helper protein 5-LO activating protein (FLAP) is necessary for efficient enzyme utilization of endogenous substrate. The last decade has witnessed remarkable progress in our understanding of these two proteins. Here we review the molecular and cellular aspects of the expression, function, and regulation of 5-LO and FLAP. (C) 2003 Elsevier Science Ltd. All rights reserved.
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