Journal
AUTOIMMUNITY
Volume 36, Issue 6-7, Pages 323-330Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930310001604207
Keywords
apoptosis; autoimmune disorders; tumor necrosis factor receptor; BCL-2; family; death receptors
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Funding
- NIAID NIH HHS [AI01821] Funding Source: Medline
- NIDDK NIH HHS [DK47417, DK44972, DK57938] Funding Source: Medline
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Apoptosis or programmed cell death plays a central role in regulating not only the development of lymphocytes but also in their homeostasis. A breakdown in apoptosis related signaling mechanisms could result in the development of autoimmune disorders. The past decade has witnessed an explosive increase in knowledge with respect to various apoptotic signaling pathways and their aberrant behavior in autoimmune disorders. Although Fas/FasL mediated signaling appears to be a common paradigm that has emerged from studies in various autoimmune disorders, examples suggesting a role for other cell death pathways have also surfaced. Understanding the definitive role of apoptosis in various autoimmune disorders is likely to define novel targets for future therapeutic intervention.
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