Journal
NATURE GENETICS
Volume 34, Issue 4, Pages 377-378Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1209
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Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution.
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