Journal
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Volume 26, Issue 8, Pages 718-722Publisher
EDITRICE KURTIS S R L
DOI: 10.1007/BF03347352
Keywords
prolactin; Sertoli cell; development; testis
Categories
Ask authors/readers for more resources
Direct effects of PRL on Sertoli cell proliferation were investigated by using Sertoli cell primary cultures isolated from both prepubertal rat and porcine testes. PRL metabolic effects were analyzed in rat Sertoli cell primary cultures. Exposure to physiological doses of PRL resulted in a significant increase (+50-60%) of basal DNA synthesis, as reflected by the pattern of [H-3] thymidine incorporation during culture; significant increases in lactate secretion (about 50%), androgen binding protein (ABP) production (about 30%) and basal protein synthesis (25-30%), as reflected in the augmented [C-14] valine incorporation, were also evident. Taken together, our present findings, indicating significant effects of PRL on Sertoli cell proliferation and metabolism, demonstrate that Sertoli cells are a potential target for PRL action at testicular level during pre-pubertal development. (C)2003, Editrice Kurtis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available