Journal
TRENDS IN NEUROSCIENCES
Volume 26, Issue 8, Pages 397-400Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(03)00199-1
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Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.
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