Journal
DEVELOPMENT
Volume 130, Issue 16, Pages 3725-3733Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.00605
Keywords
Drosophila; echinoid; Egfr; R8; retina
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Funding
- NCI NIH HHS [R01 CA 84309] Funding Source: Medline
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Precisely regulated Egfr activity is essential for normal development and cell differentiation. We demonstrate that the transmembrane protein Echinoid is required to downregulate Egfr activity in the developing Drosophila eye, ensuring a normal array of R8 photoreceptor neurons. Echinoid is an L1-type transmembrane molecule that is expressed in all cells of the eye imaginal discs and, unlike many other Egfr inhibitors, does not appear to be regulated transcriptionally. Echinoid co-precipitates with Egfr from cultured cells and eye imaginal discs, and Egfr activity promotes tyrosine phosphorylation of Echinoid. These observations suggest that Echinoid inhibits Egfr through direct interactions.
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