Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 8, Pages 1097-1100Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030044w
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Funding
- NCRR NIH HHS [P20 RR15583] Funding Source: Medline
- NIGMS NIH HHS [GM/OD 54302-02] Funding Source: Medline
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Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomyces sp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT(2a) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
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