Journal
JOURNAL OF BACTERIOLOGY
Volume 185, Issue 16, Pages 4992-4996Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.185.16.4992-4996.2003
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We report the characterization of BopE, a type III secreted protein that is encoded adjacent to the Burkholderia pseudomallei bsa locus and is homologous to Salmonella enterica SopE/SopE2. Inactivation of bopE impaired bacterial entry into HeLa cells, indicating that BopE facilitates invasion. Consistent with this notion, BopE expressed in eukaryotic cells induced rearrangements in the subcortical actin cytoskeleton, and purified BopE exhibited guanine nucleotide exchange factor activity for Cdc42 and Rac1 in vitro.
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