Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 47, Issue 8, Pages 2685-2687Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.8.2685-2687.2003
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Funding
- NIAID NIH HHS [N01-AI-25140] Funding Source: Medline
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In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 mug/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.
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