Journal
BIOMATERIALS
Volume 24, Issue 19, Pages 3213-3220Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(03)00170-4
Keywords
collagen/chitosan matrix (CCM); 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC); hepatocyte; liver
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Matrices composed of collagen and chitosan may create an appropriate environment for the regeneration of livers. In this study, we have prepared, characterized and evaluated a new collagen/chitosan matrix (CCM). The CCM was made by using crosslinking agent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) in N-hydroxysuccinimide (NHS) and a 2-morpholinoethane sulfonic acid (MES) buffer system. The chemical characteristics were evaluated by Fourier-transformed infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The mechanical strength was measured by tensile tests. The platelet deposition and hepatocyte culture experiments show that CCM has excellent blood and cell compatibility. The results suggest that the CCM is a promising candidate matrix for implantable bioartificial livers. (C) 2003 Elsevier Science Ltd. All rights reserved.
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