Journal
NATURE REVIEWS GENETICS
Volume 4, Issue 8, Pages 587-597Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1123
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There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LID. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.
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