Journal
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
Volume 22, Issue 4, Pages 253-257Publisher
AMER COLL NUTRITION
DOI: 10.1080/07315724.2003.10719301
Keywords
cystic fibrosis; vitamin E; essential fatty acids; antioxidants; oxidative stress
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While several studies have demonstrated essential fatty acid (EFA) deficiency in plasma and tissue lipids of cystic fibrosis (CF) patients, the reasons for this deficiency are not well established. It is believed that reduced EFA intake, malabsorption of fat, altered desaturase/lipase activity and defective cystic fibrosis transmembrane conductance regulator (CFTR) altering utilisation of EFA in epithelial cells contribute to the development of EFA deficiency in CF. It is likely that increased metabolism of arachiclonic acid to eicosanoids such as leukotrienes, thromboxane and prostaglandins may also be a contributing factor. Evidence is presented that elevated oxidative damage to EFA and impaired antioxidant defences, in particular vitamin E, may contribute to the development of EFA deficiency in CF. Furthermore, antioxidant supplementation in CF may improve EFA status.
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