Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 15, Issue 4, Pages 372-377Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(03)00079-7
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Funding
- NIGMS NIH HHS [R01 GM041514, R01 GM041514-18] Funding Source: Medline
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New preparations, fluorescent probes and imaging techniques are providing the means to observe the behavior of cells in the tissue environment of lymphoid organs. In particular, when combined with two-photon laser microscopy, intravital imaging of surgically exposed lymph nodes provides a unique view of lymphocyte migration and antigen presentation as it occurs within the living animal. The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients.
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