4.7 Article

Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis

Journal

CLINICAL INFECTIOUS DISEASES
Volume 37, Issue 3, Pages 319-325

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1086/375819

Keywords

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Funding

  1. NIAID NIH HHS [T32-AI07333, U01-AI-46745] Funding Source: Medline
  2. PHS HHS [N01-A1-75326] Funding Source: Medline

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A longitudinal cohort study of sexually active women 18 - 30 years of age was conducted to identify variables associated with the acquisition of herpes simplex virus type 2 (HSV-2) infections. Six hundred seventy HSV-2 - seronegative women were followed up at 4-month intervals for 1 year; acquisition of HSV-2 antibodies was detected in 32 of these women. Black race, less than or equal to12 years of education, having a new sex partner, and bacterial vaginosis (BV) were associated with HSV-2 seroconversion on univariate analysis. Antecedent HSV-1 infection was not protective against HSV-2 acquisition. After controlling for other identified risk factors in multivariable models, the diagnosis of BV remained associated with an increased risk of acquiring HSV-2 infection ( hazard ratio, 2.1; 95% confidence interval, 1.0 - 4.5; P = .05). In this study, the population attributable risk of BV for HSV-2 seroconversion was 21%. Additional studies are needed to determine whether screening and treatment of BV could reduce susceptibility to the acquisition of HSV-2 in women.

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