Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 122, Issue 3, Pages 454-456Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04452.x
Keywords
PTEN; constitutive phosphorylation; AML; Akt; prognosis
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Phosphorylation of PTEN (phosphatase and tensin homologue) affects PTEN protein stability and function. In this study, phosphorylated PTEN (pPTEN) was observed in 45 (73.8%) of 61 cases with acute myeloid leukaemia (AML). Phosphorylation of Akt and its downstream molecules [FKHR; Forkhead (Drosophila ) homologue 1; and GSK-3beta; glycogen synthase kinase 3 beta] was significantly associated with pPTEN (P < 0.001). The complete remission rates were not different with respect to pPTEN, but overall survival was significantly shorter in patients with pPTEN (P < 0.05). Constitutive PTEN phosphorylation may add insight into the molecular pathogenesis of AML, and may be a new parameter for an unfavourable outcome.
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