Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 9, Issue 15, Pages 3466-3471Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200304941
Keywords
biosensors; fluorescent probes; FRET (fluoresence resonance energy transfer); intramolecular dimer; stacking interactions
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Funding
- NIGMS NIH HHS [1R43GM60848] Funding Source: Medline
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Fluorogenic probes dual-labeled with reporter and quencher dyes use a change in fluorescence to monitor biochemical events (e.g., substrate binding or enzyme digestion). Such events change the reporter-quencher distance, which affects fluorescence. Recently, it is has been shown that static quenching through intramolecular dimers is an important mechanism that can sometimes be more efficient than Forster resonance energy transfer (FRET).
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