4.4 Article

Trifluoromethylated amino alcohols as chiral ligands for highly enantioselective Reformatsky reaction

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 32, Pages 6161-6163

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)01392-3

Keywords

trifluoromethylated amino alcohol; chiral ligand; enantioselective Reformatsky reaction

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The enantioselective Reformatsky reaction of PhCHO was achieved by the use of trifluoromethylated amino alcohols as chiral ligands to afford the corresponding optically active beta-hydroxy ester with up to 90% ee. (C) 2003 Elsevier Ltd. All rights reserved.

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