Journal
NEUROREPORT
Volume 14, Issue 11, Pages 1515-1518Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200308060-00023
Keywords
ileum; intracellular recording; myenteric neurons; neuronal excitability; orexin-A; synaptic transmission
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Orexins and orexin-receptors are localized by displaying their immunoreactivity in the enteric nervous system. Intracellular recordings were made from isolated myenteric neurons to investigate actions of orexin-A in the myenteric plexus of the guinea-pig ileum. Superfusion of orexin-A caused membrane depolarizations in a subset of S and AH neurons. Orexin-A responses were preserved in Ca2+ free/high Mg2+ solution and associated with an increase in input membrane resistance; their reversal potential was about -90 mV. Orexin-A augmented nicotinic fast EPSPs, whereas it did not affect the postsynaptic sensitivity to acetylcholine; this indicates that orexin-A increased the presynaptic release of acetylcholine. In conclusion, orexin-A contributes in the regulation of gut motility via its pre- and postsynaptic actions in the myenteric plexus.
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