Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 125, Issue 31, Pages 9372-9376Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja034358h
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Funding
- NIGMS NIH HHS [GM52190] Funding Source: Medline
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An open-ended hollow tubular structure is designed based on hydrogen-bond-directed self-assembly of a chimeric cyclic peptide subunit comprised of alternating alpha- and is an element of-amino acids. The design features a novel 1,4-disubstituted-1,2,3-triazole 6-amino acid and its utility as a peptide backbone substitute. The N-Fmoc-protected is an element of-amino acid was synthesized in high yield and optical purity in three steps from readily available starting materials and was employed in solid-phase peptide synthesis to afford the desired cyclic peptide structure. The cyclic peptide self-assembly has been studied in solution by H-1 NMR and mass spectrometry and the resulting tubular ensemble characterized in the solid state by X-ray crystallography.
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