Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1614, Issue 2, Pages 135-138Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0005-2736(03)00196-2
Keywords
thermosensitive liposome; lysolipid; PEG-lipid; disc formation
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Cryogenic transmission electron microscopy (cryo-TEM) images of lysolipid-containing thermosensitive liposomes (LTSL). revealed that open liposomes and bilayer discs appeared when liposomes were cycled through the gel (L-beta') to liquid-crystalline (L-alpha) phase transition. The amount of bilayer discs generated was dependent on the combined presence of PEG-lipid and lysolipid in the membrane. We hypothesize that micelle-forming membrane components stabilize the rim of bilayer openings and membrane discs that form when liposomes are cycled through T-C. (C) 2003 Published by Elsevier B.V.
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