Journal
FEMS MICROBIOLOGY LETTERS
Volume 225, Issue 1, Pages 155-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1097(03)00508-1
Keywords
acid resistance; RpoS; gadC; glutamate decarboxylase; Shigella flexneri
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Resistance to killing by low pH is a common feature of both Escherichia coli and Shigella flexneri. The most effective E coli acid resistance system utilizes two isoforms of glutamate decarboxylase encoded by gadA and gadB, and a putative glutamate/gamma-amino butyric acid antiporter encoded by gadC. Expression of the gad system is dependent upon the alternate sigma factor, as. We confirm that gadA, gadB, and gadC are also all dependent upon sigma(s) for their expression in S. flexneri. -10 sequences similar to the sigma(s)- 10 consensus sequence were identified by primer extension in the upstream promoters of all three genes and the transcriptional start points were identical in both E. coli and S. flexneri. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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