Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2003, Issue 16, Pages 3131-3138Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200300044
Keywords
antibiotics; bioorganic chemistry; peptides; cyclization; receptors
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A solid phase synthesis of a model system of the DE ring system of vancomycin is described. The synthesis involved biocatalytic resolutions of unnatural amino acids, is compatible with conventional solid phase peptide synthesis and contains as the key step: an on-bead SNAr cyclization. Binding of a cyclic peptide to the carboxylate of N-Ac-D-Ala was demonstrated. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
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