Journal
CARBOHYDRATE RESEARCH
Volume 338, Issue 17, Pages 1801-1806Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(03)00262-3
Keywords
lipopolysaccharide; O-polysaccharide; O-antigen; repeating unit; Pseudontonas aeruginosa
Funding
- NIAID NIH HHS [AI22535] Funding Source: Medline
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A phosphorylated core-lipid A backbone oligosaccharide that carries a disaccharide remainder of the first O-antigen repeating unit was derived by strong alkaline degradation following mild hydrazinolysis of the lipopolysaccharide of Pseudomonas aeruginosa immunotype 4 (serogroup O-1). The structure of the oligosaccharide was determined using ESI MS and NMR spectroscopy and it was demonstrated that 2-acetamido-2,6-dideoxy-D-glucose is the first monosaccharide of the O-polysaccharide that is linked to the LPS core. These data define the structure of the biological repeating unit of the O-antigen. (C) 2003 Elsevier Ltd. All rights reserved.
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