4.4 Article

Synthesis of a new conformationally constrained glycoamino acid building block

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 34, Pages 6413-6416

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)01586-7

Keywords

amino acids and derivatives; azides; glycosidation; peptide analogues/mimetics

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The synthesis of a suitably protected beta-D-glucopyranosyl-(S)-alpha-methylserine derivative-a new conformationally constrained glycosylated quaternary amino acid analogue of beta-D-glucopyranoSyl-L-serine-is described. This compound can be used as an attractive building block for the synthesis of new, constrained glycopeptides. (C) 2003 Elsevier Ltd. All rights reserved.

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