Journal
MOLECULAR BRAIN RESEARCH
Volume 116, Issue 1-2, Pages 155-158Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(03)00233-X
Keywords
Alzheimer's disease; human brain; mRNA; quantification; TaqMan; BACE; GSK-3
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beta-Secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan(TM) real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels. (C) 2003 Elsevier B.V. All rights reserved.
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