Journal
CIRCULATION
Volume 108, Issue 7, Pages 839-843Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.CIR.0000084539.58092.DE
Keywords
heart failure; statins; cholesterol; endothelium; inflammation
Funding
- NHLBI NIH HHS [R01 HL070274, R01 HL070274-02, HL-52233, R01 HL052233-07, R01 HL070274-01, R01 HL052233-05, R01 HL052233-06, R01 HL052233, P01 HL048743, P01 HL048743-120008] Funding Source: Medline
- NIDDK NIH HHS [R01 DK062729, R01 DK062729-01A1] Funding Source: Medline
- NINDS NIH HHS [P50 NS010828, P50 NS010828-290036, P01 NS010828-330036, P01 NS010828] Funding Source: Medline
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Background-Chronic heart failure is associated with inflammation and neurohormonal imbalance. The 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, exert anti-inflammatory and vascular protective effects. We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure. Methods and Results-Sixty-three patients with symptomatic, nonischemic, dilated cardiomyopathy were randomly divided into 2 groups. One group received simvastatin (n=24), and the other group received placebo (n=27). The initial dose of simvastatin was 5 mg/d, which was increased to 10 mg/d after 4 weeks. After 14 weeks, patients receiving simvastatin exhibited a modest reduction in serum cholesterol level compared with patients receiving placebo (130+/-13 versus 148+/-18, P<0.05). Patients treated with simvastatin had a lower New York Heart Association functional class compared with patients receiving placebo (2.04 +/- 0.06 versus 2.32 +/- 0.05, P<0.01). This corresponded to improved left ventricular ejection fraction in the simvastatin group (34+/-3 to 41+/-4%, P<0.05) but not in the placebo group. Furthermore, plasma concentrations of tumor necrosis factor-alpha, interleukin-6, and brain natriuretic peptide were significantly lower in the simvastatin group compared with the placebo group. Conclusions-Short-term statin therapy improves cardiac function, neurohormonal imbalance, and symptoms associated with idiopathic dilated cardiomyopathy. These findings suggest that statins may have therapeutic benefits in patients with heart failure irrespective of serum cholesterol levels or atherosclerotic heart disease.
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