Journal
MOLECULAR BRAIN RESEARCH
Volume 116, Issue 1-2, Pages 94-105Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(03)00259-6
Keywords
MAP tau; regulated isoform; membrane-interacting domain; alternative splicing; cis and trans splicing regulators
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Funding
- NINDS NIH HHS [R01 NS38051] Funding Source: Medline
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Tau is a microtubule-associated protein whose transcript undergoes complex regulated splicing in the mammalian nervous system. The N-terminal domain of the protein interacts with the axonal membrane, and is modulated by regulated inclusion of exons 2 and 3. These two tau exons are alternatively spliced cassettes, in which exon 3 never appears independently of exon 2. Previous work with tau minigene constructs indicated that exon 2 resembles a constitutive exon. In this study, we show that exon 2 is regulated by a combination of exonic and intronic enhancers and silencers. Furthermore, we demonstrate that known splicing regulators affect the ratio of exon 2 isoforms. Lastly, we tentatively pinpoint the site of action of several splicing factors which regulate tau exon 2. (C) 2003 Elsevier B.V. All rights reserved.
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