Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 17, Pages 9873-9877Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1734000100
Keywords
membrane fusion; Sit1; secretion; tail-anchored protein
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SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (SIt1). SIt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Well. Down-regulation of SIt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that SIt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.
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