Journal
ORGANIC LETTERS
Volume 5, Issue 17, Pages 3135-3137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0351910
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- NIGMS NIH HHS [GM49631] Funding Source: Medline
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The structurally intriguing cell-cycle inhibitor spirotryprostatin A has been synthesized utilizing an azomethine ylide dipolar cycloaddition reaction as the key step. This pentacyclic alkaloid contains a prenylated tryptophan-derived oxindole moiety that has been created in a reglocontrolled and stereocontrolled manner in a single step.
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