4.7 Article

Facile synthesis of flavonoid 7-O-glycosides

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 17, Pages 6842-6845

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo034553e

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Highly regioselective removal of the 7-O-acylgroups of the peracyated flavones, isoflavones, and flavonolsyl(PhSH, imidazole, NMP) followed by effective glycosylation with glycosyl trifluoroacetimidates (BF3.Et2O) and cautious deprotection of the acyl groups under basic conditions afforded the desired 7-O-flavonoid glycosides in satisfactory yields.

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