Journal
NEUROREPORT
Volume 14, Issue 12, Pages 1613-1616Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200308260-00014
Keywords
Notch1; presenilin-1; gamma-secretase
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Funding
- Canadian Institutes of Health Research [64309] Funding Source: Medline
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It has been previously demonstrated that the Notch1 signalling pathway is impaired in presenilin-1 null cells. This observation suggests a role for presenilin-1 in the Notch1 developmental pathway, possibly through physical interaction. Here, we show that presenilin-1 and Notch1 do not interact directly with each other but are associated in the cell. These findings raise the possibility that the gamma-secretase cleavage occurs via a presenilin complex in association with a putative co-factor specific for the molecule that is being cleaved (e.g. Notch1, (beta-amyloid precursor protein, E-cadherin and ErbB-4, all of which are gamma-secretase substrates).
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