Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 55, Issue 8, Pages 1043-1054Publisher
ELSEVIER
DOI: 10.1016/S0169-409X(03)00102-9
Keywords
immunotoxin; suicide transport; dermorphin; dopamine beta-hydroxylase
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Although only recently applied to the study of nociception, 'molecular neurosurgery', producing highly selective neural lesions using targeted cytotoxins, has proven a valuable tool for analysis of nociceptive systems and promises to yield much more information on the role of specific types of neurons in pain perception and possibly new pain therapies. Neuropeptide-toxin conjugates, particularly, substance P-saporin, have proven useful research tools and may find clinical applications. Targeting non-lethal moieties (enzymes, genes, viruses) also may prove useful for research and therapeutic purposes. (C) 2003 Elsevier B.V. All rights reserved.
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