Journal
NEUROSCIENCE LETTERS
Volume 347, Issue 3, Pages 179-182Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00695-5
Keywords
spinal nerve ligation; tumor necrosis factor receptors 1 and 2; dorsal root ganglia; neuropathic pain; hyperalgesia
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Funding
- NINDS NIH HHS [NS35630] Funding Source: Medline
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Evidence indicates a role for tumor necrosis factor-alpha (TNF) in neuropathic pain. We correlated pain behavior in response to mechanical stimulation with immunoreactivity for TNF receptor (TNFR) I and 2 at 6, 24, 76 and 120 h following L5 and L6 spinal nerve ligation (SNL). Allodynia began in both L4 and L5 dermatomes within 6 h following SNL, peaking by 24 h. In L5 (injured) dorsal root Ganglia (DRG), TNFR I and TNFR2 levels displayed a bimodal increase, peaking at 6 and 120 h after SNL. In L4 (uninjured) DRG, TNFR I and TNFR2 immunoreactivity peaked at 24 h returning to basal levels by 120 h. TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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