Journal
TOXICOLOGY
Volume 190, Issue 3, Pages 171-184Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0300-483X(03)00162-8
Keywords
particulate matter; epithelial cell; cell death
Categories
Funding
- NIEHS NIH HHS [P30 ES06694] Funding Source: Medline
Ask authors/readers for more resources
Inhalation of combustion-derived particulate matter can have a variety of negative impacts on human health. Metals are known to play a substantial role in these effects, however, the interactions between cellular responses caused by multiple metals is not well understood. The impact of metals (Zn, Cu, Ni, V, and Fe) individually and in combination on a rat lung epithelial cell line (RLE-6TN) was evaluated. Quantifications involved measurement of inhibition of cell culture metabolism (mitochondrial succinate dehydrogenasc activity), cell death, mechanisms of cell death, and cytokine secretion. The ranking of metal toxicity based on TC50 values is V > Zn > Cu > Ni > Fe. Interactions were observed for exposures containing multiple metals: Zn + V, Zu + Cu, Zn + Fe, and Zn + Ni. Zn appears to diminish the negative impact of V and Cu; has ail additive effect with Ni, and has no substantial effect oil Fe toxicity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available