Journal
ONCOGENE
Volume 22, Issue 36, Pages 5707-5711Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1206800
Keywords
c-Myc; P-TEFb; CycT1; apoptosis; proliferation; transcription
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c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.
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