Journal
FEMS MICROBIOLOGY LETTERS
Volume 225, Issue 2, Pages 195-200Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1097(03)00513-5
Keywords
metronidazole; Enterococcus; intestinal bacteria; nitroreductase
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Enterococcus casseliflavus and Enterococcus gallinarum strains resistant to metronidazole, nitrofurantoin and nitrofurazone were isolated from fecal samples of a patient with recurrent ulcerative colitis treated with metronidazole. Unlike other metronidazole-resistant bacteria, these strains produced nitroreductase but metabolized metronidazole to compounds that could not be detected by liquid chromatography with UV or mass spectral analysis. Metronidazole-susceptible Clostridium perfringens grew equally well in spent cultures of Enterococcus spp. incubated with or without metronidazole. These data indicate that the nitroreductases produced by these Enterococcus strains did not activate metronidazole to bactericidal metabolites and these bacteria may reduce the effectiveness of metronidazole. We have indirect evidence for an alternative pathway that results in metronidazole resistance. These strains of enterococcus had nitroreductase so resistance should not have occurred. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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