Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 14, Issue 5, Pages 675-712Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532003000500002
Keywords
natural products; combinatorial chemistry; drug discovery; lead compounds
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Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of natural product-looking libraries covering a wide range of structural diversities.
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