Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 38, Issue 8, Pages 1449-1454Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0513-3
Keywords
Mangrove; Penicillium solitum; Penipyrol; Peniamidone; Radical scavenging activity
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Funding
- National Natural Science Foundation of China [21372208, 41176120]
- National High Technology Research and Development Program of China [2013AA092901]
- State Key Laboratory of Bio-organic and Natural Products Chemistry ( [SKLBNPC12331]
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Chemical investigation the extract of Penicillium solitum GWQ-143 led to yield four new compounds penipyrols A-B (1-2) and peniamidones A-B (3-4), together with peniamidones C-D (5-6), which had been previously described as synthetic intermediates, not obtained from natural resource. The structures of those new compounds were established through extensive spectroscopic analysis. Compounds 1-6 exhibited great radical scavenging activities against DPPH with IC50 values ranged from 4.7 to 15.0 mu M.
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