Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 37, Issue 1, Pages 60-68Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0280-6
Keywords
Hydrogel; Drug delivery; Natural polymers; Synthetic polymers; Protein release
Categories
Funding
- National Research Foundation of Korea
- Korean government [2013030789]
- Brain Korea 21 plus (BK21 plus) program [22A20130011095]
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A wide variety of delivery systems have been developed and many products based on the drug delivery technology are commercially available. The development of controlled-release technologies accelerated new dosage form design by altering pharmacokinetic and pharmacodynamics profiles of given drugs, resulting in improved efficacy and safety. Various natural or synthetic polymers have been applied to make matrix, reservoir or implant forms due to the characteristics of polymers, especially ease of control for modifications of biocompatibility, biodegradation, porosity, charge, mechanical strength and hydrophobicity/hydrophilicity. Hydrogel is a hydrophilic, polymeric network capable of imbibing large amount of water and biological fluids. This review article introduces various applications of natural and synthetic polymer-based hydrogels from pharmaceutical, biomedical and bioengineering points of view.
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