Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 36, Issue 11, Pages 1279-1290Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0238-8
Keywords
Antidepressants; Neurogenesis; Alzheimer's disease; Brain derived neurotrophic factor; Depression
Categories
Funding
- Chung-Ang University
- Ministry of Knowledge Economy [10041913]
- National Research Foundation of Korea
- Korea Government (MEST) [2010-0012635]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10041913] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0012635] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Recently identified new potential functions of antidepressants in the treatment of neurodegenerative will be introduced. Antidepressants are reported to regulate stem cell fate to regenerate neurons in the adult hippocampus and are effective in reducing toxic amyloid peptides and are known to increase neurotrophic factor such as brain-derived neurotrophic factor. Clinical trial data support that antidepressants have potential to treat Alzheimer's disease.
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