Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 36, Issue 7, Pages 792-801Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0130-6
Keywords
Melanogenesis; cAMP; PKC; Hypopigmenting agents
Categories
Funding
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2011-0028962]
- Grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A103017]
- National Research Foundation of Korea [2011-0028962] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Abnormal pigmentation, particularly hyperpigmentation, is major issue of concern for people with colored skin. Several hypopigmenting agents, which exert their action by inhibiting tyrosinase activity and/or transcription, have been used for treatment. However, results have been discouraging. To manage abnormal pigmentation properly, the mechanisms of melanogenesis should be understood. Endogenous and exogenous factors affect melanogenesis via intracellular machineries. cAMP and PKC are critical factors of important transduction pathways and cross-talk between them could amplify the melanogenic effect. Here, factors involved in melanogenesis regulation via cAMP and/or PKC pathways are reviewed with their action mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available